Harrison will take up the position this month and be responsible for representing the multi-asset team in retail and institutional channels.
He will be tasked with expanding the existing business and broadening it geographically.
Harrison joins Henderson from AllenbridgeEpic where he was a senior adviser to four local government pension schemes with combined assets in excess of £8bn.
He also spent 16 years at UBS holding positions including UK chief investment officer and head of UK institutional advisory solutions.
“John’s blend of investment and client management skills is a great addition to the team,” said Bill McQuaker, co-head of multi-asset. “In addition to the wealth of investment experience he has built during his career, this will be of enormous benefit to us,” he added.
Henderson’s multi-asset team run a total of £6.3bn as at 30th April 2014.