Future of AI… Thinking outside the box

Thematics AM’s Karen Kharmandarian and Alexandre Zilliox ask why the most exciting breakthroughs can come from the least obvious of applications

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It’s often the most creative and fantastical applications of artificial intelligence (AI) that make the headlines. Think about the potential of Generative AI to create personalised movies, with the ability for audiences to pick their own actors or even insert themselves into the storyline[1].

Or how about AI powered robotic bees that could support pollination and crop development to help stem biodiversity loss against a backdrop of declining honey bee populations[2].

Yet behind the headlines, AI is being put to work in areas such as drug development and chip design. Take Google DeepMind’s AI technology AlphaFold: in November 2020, it was recognised by a community forum of scientists as having found a solution to a 50-year old biology problem[3].

For decades scientists had been trying to devise a method to reliably determine how the attraction and repulsion of amino assets leads to seemingly spontaneous protein structures with intricate curls and loops, called protein folds. The AI model that DeepMind developed, using the same foundational techniques that powered AlphaGo to victory against the legendary Go player Lee Sedol in 2016, is able to accurately predict the 3D structure of protein folds. AlphaFold’s updated database, that today contains over 200 million structures was made freely available to the world in July of 20223.

Thanks to AI innovations like AlphaFold, companies are now able to sift through billions of different molecules to simulate and understand how various drugs interact with the human body on a molecular, cellular or even genetic scale. This has the potential to significantly reduce drug development timeframes, improve success rates and ultimately reduce costs.

Moreover, AI is also being used by the same chip designers, such as Nvidia, AMD and even Alphabet, whose processors are the workhorses of Large Language Models and Machine Learning systems, be it graphic processing units (GPUs). These are particularly good at parallel computing, data processing units (DPUs), which manage data transfer, encryption and compression in data centres or Application Specific Integrated Circuits (ASICs), that are complex processors designed for specific workloads.

A single printed circuit includes a raft of very small and very complex components, with many thermal and electromagnetic exchanges between them. Optimizing their placement involves simulating their interactions, which is a very iterative process.

For example, physical implementation and verification which were long and delicate processes performed by humans for months, can now be accomplished by AI in a matter of hours. What’s more, AI models learn and build upon all previous designs and make rapid simulations to come up with new chip architectures that are even more efficient and can be tweaked along the way by engineers.

US-based Cadence Design Systems’ latest innovation for example has helped increase a chips power, performance area (PPA) by as much as 20% using generative AI design[4].

Indeed, during a conference call in June, Cadence’s General Manager of Strategy and New Ventures claimed: “Our customers are realizing transformative results with our broad Generative AI portfolio […] for instance, customers have seen up to 60% improvement in timing [and…] up to 10x increased engineering productivity.”

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Karen Kharmandarian and Alexandre Zilliox are portfolio managers at Thematics AM, an affiliate of Natixis Investment Managers

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[1] Source: https://www.forbes.com/sites/kalevleetaru/2019/04/23/could-ai-replace-hollywood-with-personalized-movies/

[2] Source: https://isr.umd.edu/news/story/autonomous-drones-based-on-bees-use-ai-to-work-together

[3] Source: https://www.deepmind.com/research/highlighted-research/alphafold

[4] Source: https://www.forbes.com/sites/karlfreund/2023/06/13/cadence-ai-can-increase-chip-designer-productivity-by-over-10x

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