It is understood investment manager Susanne Evans is among those who have been made redundant after only being promoted to the role in November.
A spokesperson for the private client investment managers, said: "It is regrettable to have to make any redundancies, but in the current climate we needed to restructure the Aberdeen office in line with market requirements.
"We have therefore made five redundancies, only one of whom was directly client facing. The high standards that we set in client services will be unaffected by this decision."
On its website Brewin refers to the pedigree of the Aberdeen office, roots of which it said can be traced back to the middle of the 18th century.
Brewin announced on 12 January the expansion of its London office, with the hire of four executives in financial planning and charity investment management.
At the time, David McCorkell head of investment management, said of the recruits: "Their arrival signifies our plans for growth and the development of these two important areas of the business."
In its full-year results Brewin reported a 27% fall in pre-tax profit from £30m to £21.9m. A large chunk of the slump was down to a £6m FSCS levy.
As well as the new office in Bristol, which opened its doors earlier this month, the firm said it was adding to its teams in Glasgow and Leeds.